Detalhe da pesquisa
1.
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.
Gastroenterology
; 163(6): 1593-1612, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35948109
2.
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
Gastroenterology
; 149(7): 1932-1943.e9, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26255562
3.
Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer.
Cancer Res
; 84(8): 1320-1332, 2024 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38285896
4.
Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer.
Cancer Res Commun
; 3(7): 1224-1236, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37448553
5.
Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.
Cancer Discov
; 13(6): 1428-1453, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36946782
6.
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
Biochim Biophys Acta
; 1816(2): 209-18, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21807066
7.
Interleukin-1 signaling in solid organ malignancies.
Biochim Biophys Acta Rev Cancer
; 1877(1): 188670, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34923027
8.
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.
Oncogene
; 41(28): 3640-3654, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35701533
9.
Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma.
Mol Cancer Ther
; 20(7): 1246-1256, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34001634
10.
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer.
Mol Cancer Ther
; 20(11): 2280-2290, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34518296
11.
Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Mol Cancer Res
; 18(4): 623-631, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31949002
12.
Src kinase inhibition restores E-cadherin expression in dasatinib-sensitive pancreatic cancer cells.
Oncotarget
; 10(10): 1056-1069, 2019 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30800218
13.
Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer.
Mol Cancer Ther
; 18(2): 301-311, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30404927
14.
Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.
DNA Repair (Amst)
; 83: 102644, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311767
15.
Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.
Cancer Res
; 78(21): 6146-6158, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232221
16.
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.
Cancer Res
; 78(21): 6235-6246, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30154150
17.
Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth.
Oncotarget
; 8(49): 85378-85391, 2017 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29156726
18.
Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response.
Pancreas
; 45(6): 863-9, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26495796
19.
Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells.
Oncotarget
; 7(40): 65982-65992, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27602757
20.
New mechanistic insights into modifiable risk factors that promote pancreatic cancer.
Oncotarget
; 10(25): 2417-2418, 2019 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31069003